RNase-free Disposable Consumables RNASEフリーバッグ
RNase-free Disposable Consumables
mRNA is a new-generation technology platform that is expected to change traditional ways of vaccines and monoclonal anti-body development and manufacturing. Due to its short R&D cycle, simple production process, strong immunogenicity, and high safety, mRNA has the potential to be widely applied in various fields such as vaccines for infectious diseases, tumor immunology, and recombinant protein. Even though mRNA vaccines are booming, the mRNA drugs are in low profile. To date, there is no particularly welcomed mRNA drug, mainly due to the difficulty of mRNA drug development - the higher the purity, the stronger the druggability. However, due to ubiquitous RNase in the environment, mRNA is easily contaminated, which is why Moderna has invested heavily in building a nuclease-free laboratory (RNase-free Lab). The construction costs are as high as tens of millions of dollars; and with subsequent operations and maintenance, the cost requires an investment of hundreds of millions of dollars. This is possibly why the development of many mRNA drugs is stalled. Ribonuclease (RNase) is a class of nucleic acid hydrolases that are widely found in animals and plants. Due to its "ubiquitous" nature, it is necessary to take multiple and complex clean-ups to eliminate the effects of RNase in the mRNA production process, which greatly reduces production efficiency. Meanwhile, the process validation and verification of RNase removal are also time-consuming and labor-intensive. Therefore, RNase-free disposable consumables are highly welcomed by mRNA manufacturers using single-use bioprocess technology for production. In addition, the RNase level within those consumables shall be inspected before
release and can be verified post-use without damage.
As a supplier of bioprocess disposable equipment and consumables for bioprocessing, GVS has launched an innovative design and comprehensive solution of master bag + double satellite bags for the first time with 100% RNase/DNase inspection and release of products as well as customer verification.
mRNA is a new-generation technology platform that is expected to change traditional ways of vaccines and monoclonal anti-body development and manufacturing. Due to its short R&D cycle, simple production process, strong immunogenicity, and high safety, mRNA has the potential to be widely applied in various fields such as vaccines for infectious diseases, tumor immunology, and recombinant protein. Even though mRNA vaccines are booming, the mRNA drugs are in low profile. To date, there is no particularly welcomed mRNA drug, mainly due to the difficulty of mRNA drug development - the higher the purity, the stronger the druggability. However, due to ubiquitous RNase in the environment, mRNA is easily contaminated, which is why Moderna has invested heavily in building a nuclease-free laboratory (RNase-free Lab). The construction costs are as high as tens of millions of dollars; and with subsequent operations and maintenance, the cost requires an investment of hundreds of millions of dollars. This is possibly why the development of many mRNA drugs is stalled. Ribonuclease (RNase) is a class of nucleic acid hydrolases that are widely found in animals and plants. Due to its "ubiquitous" nature, it is necessary to take multiple and complex clean-ups to eliminate the effects of RNase in the mRNA production process, which greatly reduces production efficiency. Meanwhile, the process validation and verification of RNase removal are also time-consuming and labor-intensive. Therefore, RNase-free disposable consumables are highly welcomed by mRNA manufacturers using single-use bioprocess technology for production. In addition, the RNase level within those consumables shall be inspected before
release and can be verified post-use without damage.
As a supplier of bioprocess disposable equipment and consumables for bioprocessing, GVS has launched an innovative design and comprehensive solution of master bag + double satellite bags for the first time with 100% RNase/DNase inspection and release of products as well as customer verification.
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